A SQLitePCL.raw 'provider' bridges the gap between SQLitePCLRaw.core and a particular instance of the native SQLite library. Install this package in your app project and call SQLitePCL.raw.SetProvider(new SQLitePCL.SQLite3Provider_sqlcipher()); Depending on the platform, you may also need to add one of the SQLitePCLRaw.lib.* packages. Convenience packages are named SQLitePCLRaw.bundle_*.